Triacsin C
Cat. No.：YN483353
CAS No. ：76896-80-5
| 产品名称: | Triacsin C |
| CAS No.: | 76896-80-5 |
| Chemical Name: | 2E,4E,7E-undecatrienal, nitrosohydrazone |
| Synonyms: | WS 1228A; FR 900190 |
| 分子量: | 207.27 |
| 分子式: | C₁₁H₁₇N₃O |
| SMILES: | CCC/C=C/C/C=C/C=C/C=N/NN=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ，是一种天然细胞内长链酰基辅酶A合成酶 (ACSL)抑制剂。Triacsin C 通过抑制ACSL来抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 对轮状病毒复制非常有效。 |
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Tomoda, H., Igarashi, K., Cyong, J.C., et al.Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferationJ. Biol. Chem.266,4214-4219(1991)
Igal, R.A., Wang, P., and Coleman, R.A.Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoABiochem. J.324(Pt 2),529-534(1997)
Weis, M.T., Crumley, J.L., Young, L.H., et al.Inhibiting long chain fatty acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endotheliumCardiovasc. Res.63(2),338-346(2004)
Zhao, Y., Wang, L., Qiu, J., et al.Linoleic acid stimulates [Ca2+]i increase in rat pancreaticβcells through both membrane receptor- and intracellular metabolite-mediated pathwaysPLoS One8(4),e60255(2013)
