Baccatin III
Cat. No.：YN483477
CAS No. ：27548-93-2
| 产品名称: | Baccatin III |
| CAS No.: | 27548-93-2 |
| Chemical Name: | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one |
| Synonyms: | 巴卡亭 Ⅲ |
| 分子量: | 586.63 |
| 分子式: | C₃₁H₃₈O₁₁ |
| SMILES: | O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](O)C[C@@]2(O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]1(C)[C@@H](O)C[C@@]5([H])OC[C@]54OC(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Baccatin III 是一种从太平洋紫杉树和其近缘种中分离出的一种天然产物。Baccatin III 能通过减少 MDSCs 积累和抑制其功能，延缓肿瘤发展进程。 |
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Chakravarthi, B.V., Sujay, R., Kuriakose, G.C., et al.Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solaniCancer Cell Int.13(1),(2013)
Lee, Y.-H., Lee, Y.-R., Kim, K.-H., et al.Baccatin III, a synthetic precursor of taxol, enhances MHC-restricted antigen presentation in dendritic cellsInt. Immunopharmacol.11(8),982-991(2011)
Lee, Y.-H., Lee, Y.-R., Park, C.-S., et al.Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing miceInt. Immunopharmacol.21(2),487-493(2014)
