Withanolide A
Cat. No.：YN483506
CAS No. ：32911-62-9
| 产品名称: | Withanolide A |
| CAS No.: | 32911-62-9 |
| Chemical Name: | 6α,7α-epoxy-5α,20,22R-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone |
| Synonyms: | |
| 分子量: | 470.60 |
| 分子式: | C₂₈H₃₈O₆ |
| SMILES: | O=C1O[C@@]([H])([C@@](C)([C@H]2CC[C@]3([C@@]4([C@H]5[C@@H]([C@@](O)(CC=CC6=O)[C@]6([C@]4(CC[C@@]32C)[H])C)O5)[H])[H])O)CC(C)=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Withanolide A 是从印度草药Ashwagandha中提取得到的，在严重受损的神经元中，能再生神经元突并重建突触。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kurapati, K.R.V., Samikkannu, T., Atluri, V.S.R., et al.β-Amyloid1-42, HIV-1Bα-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide APLoS One9(11),1-23(2014)
Zhao, J., Nakamura, N., Hattori, M., et al.Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activitiesChem. Pharm. Bull. (Tokyo)50(6),760-765(2002)
Kuboyama, T., Tohda, C., and Komatsu, K.Neuritic regeneration and synaptic reconstruction induced by withanolide ABr. J. Pharmacol.144(7),961-971(2005)
Baitharu, I., Jain, V., Deep, S.N., et al.Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxiaPLoS One9(10),1-17(2014)
