7α-Hydroxycholesterol
Cat. No.：YN483572
| 产品名称: | 7α-Hydroxycholesterol |
| CAS No.: | 566-26-7 |
| Chemical Name: | cholest-5-ene-3β,7α-diol |
| Synonyms: | |
| 分子量: | 402.65 |
| 分子式: | C₂₇H₄₆O₂ |
| SMILES: | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7α-Hydroxycholesterol 是一种胆固醇氧化物，由酶促氧化和非酶促氧化形成。7α-Hydroxycholesterol 可用作脂质过氧化的生物标志物。 |
| IC50和靶点: | |
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Mitropoulos, K.A., and Balasubramaniam, S.Cholesterol 7α-hydroxylase in rat liver microsomal preparationsBiochem. J.128(1),1-9(1972)
Chiang, J.Y.L.Bile acid metabolism and signaling in liver disease and therapyLiver Res.1(1),3-9(2017)
Lemaire, S., Lizard, G., Monier, S., et al.Different patterns of IL-1β secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7α-, 7β-hydroxycholesterol, or 7-ketocholesterolFEBS Lett.440(3),434-439(1998)
Kim, S.M., Kim, B.Y., Son, Y., et al.7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2Biochem. Biophys. Res. Commun.467(4),879-884(2015)
Hultén, L.M., Lindmark, H., Diczfalusy, U., et al.Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophagesJ. Clin. Invest.97(2),461-468(1996)
