3-Deoxyglucosone
Cat. No.：YN483591
| 产品名称: | 3-Deoxyglucosone |
| CAS No.: | 4084-27-9 |
| Chemical Name: | 3-deoxy-D-erythro-hexos-2-ulose |
| Synonyms: | 3-Deoxy-D-glucosone |
| 分子量: | 162.14 |
| 分子式: | C₆H₁₀O₅ |
| SMILES: | OC[C@@H](O)[C@@H](O)CC(C=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Deoxyglucosone (3-Deoxy-D-glucosone) 是美拉德反应和多元醇途径的反应中间体 (intermediate)。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化终产物 (AGEs)，例如咪唑啉酮，它是 3-DG 的最特异 AGE。3-Deoxyglucosone 可以与低葡萄糖协同作用以增强GLP-1分泌，可以作为糖尿病生物学检测的标志物。 |
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Yamada, H., Miyata, S., Igaki, N., et al.Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reactionJ. Biol. Chem.269(32),20275-20280(1994)
Kusunoki, H., Miyata, S., Ohara, T., et al.Relation between serum 3-deoxyglucosone and development of diabetic microangiopathyDiabetes Care26(6),1889-1894(2003)
Niwa, T., and Tsukushi, S.3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosoneKidney Int. Suppl.78,S37-S41(2001)
Thornalley, P.J., Langborg, A., and Minhas, H.S.Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucoseBiochem. J.344(Pt 1),109-116(1999)
