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N-Desmethyl Galanthamine

Cat. No.:YN483631

  • CAS No. :41303-74-6

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    • 参考文献
    • 产品名称: N-Desmethyl Galanthamine
      CAS No.: 41303-74-6
      Chemical Name: (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
      Synonyms:N-Norgalanthamine
      分子量:273.33
      分子式:C₁₆H₁₉NO₃
      SMILES:O[C@H]1C=C[C@@]23CCNCC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: N-Desmethyl Galanthamine 是的 Galanthamine 的代谢物。Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50为 500 nM。
      IC50和靶点:
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      In Vivo:
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    • Kobayashi, S., Ishikawa, H., Kihara, M., et al.Isolation of N-demethylgalanthamine from the bulbs of Crinum asiaticum L. var. japanicum Baker (Amaryllidaceae)Chem. Pharm. Bull.24(10),2553-2555(1976)

      Kowal, N.M., Indurthi, D.C., Ahring, P.K., et al.Novel approach for the search for chemical scaffolds with activity at both acetylcholinesterase and the α7 nicotinic acetylcholine receptor: A perspective on scaffolds with dual activity for the treatment of neurodegenerative disordersMolecules24(3),446(2019)

      Maláková, J., Nobilis, M., Svoboda, Z., et al.High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.853(1-2),265-274(2007)

      Weniger, B., Italiano, L., Beck, J.-P., et al.Cytotoxic activity of amaryllidaceae alkaloidsPlanta Med.61(1),77-79(1995)

      Yang, N., Ko, M., Ahn, M., et al.Hepatoprotective effects of norgalanthamine on carbon tetrachloride induced-hepatotoxicity in miceDrug Chem. Toxicol.,(2021)

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