N-Desmethyl Galanthamine
Cat. No.：YN483631
| 产品名称: | N-Desmethyl Galanthamine |
| CAS No.: | 41303-74-6 |
| Chemical Name: | (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol |
| Synonyms: | N-Norgalanthamine |
| 分子量: | 273.33 |
| 分子式: | C₁₆H₁₉NO₃ |
| SMILES: | O[C@H]1C=C[C@@]23CCNCC4=CC=C(OC)C(O[C@@]3([H])C1)=C24 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N-Desmethyl Galanthamine 是的 Galanthamine 的代谢物。Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，IC50为 500 nM。 |
| IC50和靶点: | |
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Kobayashi, S., Ishikawa, H., Kihara, M., et al.Isolation of N-demethylgalanthamine from the bulbs of Crinum asiaticum L. var. japanicum Baker (Amaryllidaceae)Chem. Pharm. Bull.24(10),2553-2555(1976)
Kowal, N.M., Indurthi, D.C., Ahring, P.K., et al.Novel approach for the search for chemical scaffolds with activity at both acetylcholinesterase and the α7 nicotinic acetylcholine receptor: A perspective on scaffolds with dual activity for the treatment of neurodegenerative disordersMolecules24(3),446(2019)
Maláková, J., Nobilis, M., Svoboda, Z., et al.High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.853(1-2),265-274(2007)
Weniger, B., Italiano, L., Beck, J.-P., et al.Cytotoxic activity of amaryllidaceae alkaloidsPlanta Med.61(1),77-79(1995)
Yang, N., Ko, M., Ahn, M., et al.Hepatoprotective effects of norgalanthamine on carbon tetrachloride induced-hepatotoxicity in miceDrug Chem. Toxicol.,(2021)
