NFAT Inhibitor
Cat. No.：YN483816
| 产品名称: | NFAT Inhibitor |
| CAS No.: | 249537-73-3 |
| Chemical Name: | L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid |
| Synonyms: | VIVIT peptide |
| 分子量: | 1685.94 |
| 分子式: | C₇₅H₁₂₀N₂₀O₂₂S |
| SMILES: | O=C(N(CCC1)[C@@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)CC)([H])C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)CC)([H])C(N[C@]([C@H](O)C)([H])C(NCC(N(CCC2)[C@@H]2C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC3=CNC=N3)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CNC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NFAT Inhibitor (VIVIT peptide) 是一种NFAT的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的NFAT脱磷酸作用。 |
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Aramburu, J., Yaffe, M.B., López-Rodríguez, C., et al.Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin AScience285(5436),2129-2133(1999)
Roehrl, M.H.A., Kang, S., Aramburu, J., et al.Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic moleculesProc. Natl. Acad. Sci. USA101(20),7554-7559(2004)
Yu, H., Sliedregt-Bol, K., Overkleeft, H., et al.Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agentArterioscler. Thromb. Vasc. Biol.26(7),1531-1537(2006)
