Cyclosporin H
Cat. No.：YN483837
| 产品名称: | Cyclosporin H |
| CAS No.: | 83602-39-5 |
| Chemical Name: | 5-(N-methyl-D-valine)-cyclosporin A |
| Synonyms: | Cyclosporin H;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];Cyclosporin H, froM MicroMonospora;cyclosi |
| 分子量: | 1202.61 |
| 分子式: | C₆₂H₁₁₁N₁₁O₁₂ |
| SMILES: | O([H])C([H])(C([H])(C([H])([H])[H])C([H])([H])C([H])=C([H])C([H])([H])[H])C1([H])C(N([H])C([H])(C(N(C([H])([H])[H])C([H])([H])C(N(C([H])([H])[H])C([H])(C(N([H])C([H])(C(N(C([H])([H])[H])C([H])(C(N([H])C([H])(C([H])([H])[H])C(N([H])C([H])(C([H])([H])[H])C( |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cyclosporin H, aviral transductionenhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin or prostaglandi |
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Wenzel-Seifert, K., and Siefert, R.Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and EJ. Immunol.150(10),4591-4599(1993)
Yan, P., Nanamori, M., Sun, M., et al.The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand bindingJ. Immunol.177(10),7050-7058(2006)
Zhou, C., Zhou, Y., Wang, J., et al.V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporinsBiochem. J.451(2),245-255(2013)
Sherry, B., Yarlett, N., Strupp, A., et al.Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophagesProc. Natl. Acad. Sci. USA89(8),3511-3515(1992)
Gschwendt, M., Kittstein, W., and Marks, F.The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitroBiochem. Biophys. Res. Commun.150(2),545-551(1988)
