2-Chloroadenosine
Cat. No.：YN484316
CAS No. ：146-77-0
| 产品名称: | 2-Chloroadenosine |
| CAS No.: | 146-77-0 |
| Chemical Name: | 2-chloro-adenosine |
| Synonyms: | |
| 分子量: | 301.69 |
| 分子式: | C₁₀H₁₂ClN₅O₄ |
| SMILES: | ClC1=NC(N)=C(N=CN2[C@@]3([H])[C@@](O)([H])[C@@](O)([H])[C@@](O3)([H])CO)C2=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 2-Chloroadenosine 是一种腺苷类似物，可防止大鼠海马缺血细胞长期丢失。2-Chloroadenosine 是尿苷内流 (uridine influx) (表观 Ki=33 μM) 的竞争性抑制剂，高亲和力与硝基苄基硫肌苷结合 (表观 Ki=0.18 mM)。2-Chloroadenosine 是人红细胞核苷转运体的转运渗透剂。 |
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Mathôt, R.A.A., Soudijn, W., Breimer, D.D., et al.Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivoBr. J. Pharmacol.118(2),369-377(1996)
Ates, N., Ilbay, G., and Sahin, D.Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine applicationExp. Biol. Med. (Maywood)230(7),501-505(2005)
Manzini, S., and Ballati, L.2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigsBr. J. Pharmacol.100(2),251-256(1990)
