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Oxfenicine

Cat. No.:YN484415

  • CAS No. :32462-30-9

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    • 生物活性
    • 参考文献
    • 产品名称: Oxfenicine
      CAS No.: 32462-30-9
      Chemical Name: αS-amino-4-hydroxy-benzeneacetic acid
      Synonyms:L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842
      分子量:167.16
      分子式:C₈H₉NO₃
      SMILES:O=C(O)[C@@H](N)C1=CC=C(O)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Oxfenicine (L-p-Hydroxyphenylglycine) 是一种具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。Oxfenicine 可抑制心脏中脂肪酸的氧化。Oxfenicine 在缺血期间保护心脏免受坏死组织的损害。
      IC50和靶点:
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      In Vivo:
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    • Barnish, I.T., Cross, P.E., Danilewicz, J.C., et al.Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acidsJ. Med. Chem.24(4),399-404(1981)

      Bielefeld, D.R., Vary, T.C., and Neely, J.R.Inhibition of carnitine palmitoyl-CoA transferase activity and fatty acid oxidation by lactate and oxfenicine in cardiac muscleJ. Mol. Cell. Cardiol.17(6),619-625(1985)

      Higgins, A.J., Morville, M., Burges, R.A., et al.Oxfenicine diverts rat muscle metabolism from fatty acid to carbohydrate oxidation and protects the ischaemic rat heartLife Sci.27(11),963-970(1980)

      Burges, R.A., Gardiner, D.G., and Higgins, A.J.Protection of the ischaemic dog heart by oxfenicineLife Sci.29(18),1847-1853(1981)

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