Cyclosporin D
Cat. No.：YN484421
| 产品名称: | Cyclosporin D |
| CAS No.: | 63775-96-2 |
| Chemical Name: | 7-L-valine-cyclosporin A |
| Synonyms: | |
| 分子量: | 1216.64 |
| 分子式: | C₆₃H₁₁₃N₁₁O₁₂ |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cyclosporin D 是 Cyclosporin A 的代谢产物，是一种弱免疫抑制剂。Cyclosporin D 作为 Cyclosporin A 定量的内标，Cyclosporin A 是一种免疫抑制药物，通过抑制钙调磷酸酶和钙调磷酸酶依赖性转录因子激活的T细胞核因子 (NFAc) 来抑制 T 细胞活化。 |
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Jorgensen, K.A., Koefoed-Nielsen, P.B., and Karamperis, N.Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimusScand. J. Immunol.57(2),93-98(2003)
Vollenbroeker, B., Koch, J.H., Fobker, M., et al.Determination of cyclosporine and its metabolites in blood via HPLC-MS and correlation to clinically important parametersTransplant. Proc.37(4),1741-1744(2005)
von Wartburg, A., and Traber, R.Cyclosporins, fungal metabolites with immunosuppressive activitiesProg. Med. Chem.25,1-33(1988)
Copeland, K.R., Yatscoff, R.W., and McKenna, R.M.Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonanceClin. Chem.36(2),225-229(1990)
Kaiser, P., Akerboom, T., Wood, W.G., et al.A new approach for the determination of immunosuppressive drugs using HPLC-MS/MS and Cs+ adductsGer. Med. Sci.4,1-12(2006)
