CBR-5884
Cat. No.：YN480002
CAS No. ：681159-27-3
规格
价格(RMB)
库存
| 产品名称: | CBR-5884 |
| CAS No.: | 681159-27-3 |
| Chemical Name: | 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid, ethyl ester |
| Synonyms: | 5-[(2-Furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid ethyl ester;CBR 5884;CBR-5884 |
| 分子量: | 336.39 |
| 分子式: | C₁₄H₁₂N₂O₄S₂ |
| SMILES: | O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CBR-5884 是一种有效，选择性的磷酸甘油酸脱氢酶 (PHGDH)抑制剂，IC50为 33 μM。 CBR-5884 抑制癌细胞中的丝氨酸合成，并且对具有高丝氨酸生物合成活性的癌细胞系具有选择性毒性。 CBR-5884 选择性地抑制黑素瘤和乳腺癌细胞系的增殖。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mullarky, E., Lucki, N.C., Zavareh, R.B., et al.Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancersProc. Natl. Acad. Sci. USA113(7),1778-1783(2016)
