LOC14
Cat. No.：YN480062
CAS No. ：877963-94-5
规格
价格(RMB)
库存
| 产品名称: | LOC14 |
| CAS No.: | 877963-94-5 |
| Chemical Name: | 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
| Synonyms: | LOC 14;LOC14 |
| 分子量: | 317.41 |
| 分子式: | C₁₆H₁₉N₃O₂S |
| SMILES: | O=C(C(C=CC=C1)=C1S2)N2CN3CCN(C(C4CC4)=O)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LOC14 是蛋白质二硫键异构酶 (PDI) 抑制剂 (EC50=500 nM;Kd=62 nM)。LOC14 在小鼠肝微粒体和血浆中表现出高稳定性，低内在微粒体清除率和低血浆蛋白结合。LOC14 抑制 PDIA3 活性，降低肺上皮细胞中 HA 的分子内二硫键和随后的寡聚化。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kaplan, A., Gaschler, M.M., Dunn, D.E., et al.Small molecule-induced oxidation of protein disulfide isomerase is neuroprotectiveProc. Natl. Acad. Sci. USA112(17),E2245-E2252(2015)
