PACMA 31
Cat. No.：YN480063
CAS No. ：1401089-31-3
规格
价格(RMB)
库存
| 产品名称: | PACMA 31 |
| CAS No.: | 1401089-31-3 |
| Chemical Name: | N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine, ethyl ester |
| Synonyms: | PACMA 31 |
| 分子量: | 430.47 |
| 分子式: | C₂₁H₂₂N₂O₆S |
| SMILES: | COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PACMA 31 是一种不可逆的口服活性蛋白二硫化物异构酶(PDI)抑制剂，IC50为 10μM，PACMA 31 与 PDI 的活性部位半胱氨酸形成共价键。PACMA 31 具有肿瘤靶向性，能显著抑制卵巢肿瘤生长，对正常组织无毒性。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
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Yan, B., Ai, Y., Sun, Q., et al.Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1Mol. Cell81(2),1-15(2020)
Chen, Y.-C., Oses-Prieto, J.A., Pope, L.E., et al.Reactivity-based probe of the iron(II)-dependent interactome identifies new cellular modulators of ferroptosisJ. Am. Chem. Soc.142(45),19085-19093(2020)
