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Bimosiamose

Cat. No.:YN480291

  • CAS No. :187269-40-5

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    • 产品名称: Bimosiamose
      CAS No.: 187269-40-5
      Chemical Name: 3′,3′′′-(1,6-hexanediyl)bis[6′-(α-D-mannopyranosyloxy)-[1,1′-biphenyl]-3-acetic acid
      Synonyms:TBC-1269
      分子量:862.91
      分子式:C₄₆H₅₄O₁₆
      SMILES:OC[C@H]([C@@H](O)[C@H](O)[C@@H]1O)O[C@@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@@H]6O)CO
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Bimosiamose (TBC-1269) 是一种非寡糖泛-selectin拮抗剂,对E-selectin,P-selectin和L-selectin的IC50分别为 88 μM,20 μM 和 86μM。Bimosiamose 具有抗炎作用。
      IC50和靶点:
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    • Palma-Vargas, J.M., Toledo-Pereyra, L., Dean, R.E., et al.Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusionJ. Am. Coll. Surg.185(4),365-372(1997)

      Friedrich, M., Bock, D., Philipp, S., et al.Pan-selectin antagonism improves psoriasis manifestation in mice and manArch. Dermatol. Res.297(8),345-351(2008)

      Aydt, E., and Wolff, G.Development of synthetic pan-selectin antagonists: A new treatment strategy for chronic inflammation in asthmaPathobiology70(5),297-301(2002)

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