SC-26196
Cat. No.：YN480326
CAS No. ：218136-59-5
规格
价格(RMB)
库存
| 产品名称: | SC-26196 |
| CAS No.: | 218136-59-5 |
| Chemical Name: | α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile |
| Synonyms: | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 |
| 分子量: | 423.55 |
| 分子式: | C₂₇H₂₉N₅ |
| SMILES: | N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Obukowicz, M.G., Welsch, D.J., Salsgiver, W.J., et al.Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in miceJ. Pharmacol. Exp. Ther.287(1),157-166(1998)
Harmon, S.D., Kaduce, T.L., Manuel, T.D., et al.Effect of the Δ6-desaturase inhibitor SC-26196 on PUFA metabolism in human cellsLipids38(4),469-476(2003)
Mulligan, C.M., Le, C.H., deMooy, A.B., et al.Inhibition of Δ-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory functionJ. Gerontol. A Biol. Sci. Med. Sci.69(7),799-809(2014)
