PKG drug G1
Cat. No.:YN480524
产品名称: | PKG drug G1 |
CAS No.: | 374703-78-3 |
Chemical Name: | 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-4-imidazolidinone |
Synonyms: | |
分子量: | 257.31 |
分子式: | C₁₃H₁₁N₃OS |
SMILES: | O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | PKG drug G1 靶向作用于PKG Iα。PKG drug G1 通过 C42 PKGIα 非依赖性机制有助于血管舒张和血压降低。 |
IC50和靶点: | |
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Burgoyne, J.R., Prysyazhna, O., Richards, D.A., et al.Proof of principle for a novel class of antihypertensives that target the oxidative activation of PKG Iα (protein kinase G Iα)Hypertension70(3),577-586(2017)