PH-002
Cat. No.：YN480568
CAS No. ：1311174-68-1
规格
价格(RMB)
库存
| 产品名称: | PH-002 |
| CAS No.: | 1311174-68-1 |
| Chemical Name: | 4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester |
| Synonyms: | PH002,PH-002,PH 002 |
| 分子量: | 491.58 |
| 分子式: | C₂₇H₃₃N₅O₄ |
| SMILES: | O=C(N1CCN(CC2=CC=C(NC(CC3=NN(C)C(C4=C3C=CC=C4)=O)=O)C=C2)CC1)OC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PH-002 是一种抑制载脂蛋白(apo) E4神经内分子相互作用的抑制剂，其IC50(FRET) 值为116 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Chen, H.-K., Liu, Z., Meyer-Franke, A., et al.Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neuronsJ. Biol. Chem.287(8),5253-5266(2012)
Brodbeck, J., McGuire, J., Liu, Z., et al.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctorsJ. Biol. Chem.286(19),17217-17226(2011)
