NVS-ZP7-4
Cat. No.：YN480618
CAS No. ：2349367-89-9
规格
价格(RMB)
库存
| 产品名称: | NVS-ZP7-4 |
| CAS No.: | 2349367-89-9 |
| Chemical Name: | 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4′(1′H)-quinazolin]-2′(3′H)-one |
| Synonyms: | |
| 分子量: | 501.62 |
| 分子式: | C₂₈H₂₈FN₅OS |
| SMILES: | O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVS-ZP7-4 是一种锌转运体 SLC39A7(ZIP7)的抑制剂，也是第一个报道的能探测内质网锌水平影响的化学分子，研究ZIP7 作为Notch 通路中的一种新的药物节点。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Nolin, E., Gans, S., Llamas, L., et al.Discovery of a ZIP7 inhibitor from a Notch pathway screenNat. Chem. Biol.15(2),179-188(2019)
Chen, P.-H., Wu, J., Xu, Y., et al.Zinc transporter ZIP7 is a novel determinant of ferroptosisCell Death Dis.12(2),198(2021)
