JH295
Cat. No.：YN480654
CAS No. ：1311143-71-1
规格
价格(RMB)
库存
| 产品名称: | JH295 |
| CAS No.: | 1311143-71-1 |
| Chemical Name: | (Z)-N-(3-((2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)propiolamide |
| Synonyms: | |
| 分子量: | 320.35 |
| 分子式: | C₁₈H₁₆N₄O₂ |
| SMILES: | C#CC(NC1=CC2=C(NC(/C2=C\C3=C(C)N=C(CC)N3)=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JH295 是一种有效，不可逆和选择性的NIMA-related kinase 2 (Nek2)抑制剂，IC50为 770 nM。JH295 通过 Cys22 的烷基化抑制细胞Nek2。JH295 对有丝分裂激酶 Cdk1，Aurora B 或 Plk1 没有活性，并且不会干扰双极纺锤体组件或纺锤体组件检查点。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Henise, J. C., et al.: J. Med. Chem., 54, 4133 (2011)
