NCT-502
Cat. No.：YN480667
CAS No. ：1542213-00-2
规格
价格(RMB)
库存
| 产品名称: | NCT-502 |
| CAS No.: | 1542213-00-2 |
| Chemical Name: | N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide |
| Synonyms: | N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide |
| 分子量: | 395.45 |
| 分子式: | C₁₈H₂₀F₃N₅S |
| SMILES: | S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NCT-502 是一种磷酸甘油酸脱氢酶 (PHGDH) 抑制剂，对 PHGDH 依赖性癌细胞具有细胞毒性，减少葡萄糖衍生的丝氨酸的产生，对 PHGDH 的IC50值为 3.7 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pacold, M.E., Brimacombe, K.R., Chan, S.H., et al.A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fateNat. Chem. Biol.12(6),452-458(2016)
