Ikarugamycin
Cat. No.：YN480715
CAS No. ：36531-78-9
规格
价格(RMB)
库存
| 产品名称: | Ikarugamycin |
| CAS No.: | 36531-78-9 |
| Chemical Name: | (2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione |
| Synonyms: | 斑鸠霉素 |
| 分子量: | 478.62 |
| 分子式: | C₂₉H₃₈N₂O₄ |
| SMILES: | O=C(/C=C/[C@@H]1C[C@]2([C@@]([H])([C@H]1C/C=C\3)C=C[C@@]4([C@@]2(C[C@H]([C@H]4CC)C)[H])[H])[H])C5=C([C@@H](NC5=O)CCCNC3=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ikarugamycin 是一种抗生素，也是一种网格蛋白介导的内吞(CME)抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jomon, K., Kuroda, Y., Ajisaka, M., et al.A new antibiotic, ikarugamycinJ. Antibiot. (Tokyo)25(5),271-280(1972)
Popescu, R., Heiss, E.H., Ferk, F., et al.Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cellsMutat. Res.709-710,60-66(2011)
Hasumi, K., Shinohara, C., Naganuma, S., et al.Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycinEur. J. Biochem.205(2),841-846(1992)
Luo, T., Fredericksen, B.L., Hasumi, K., et al.Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinJ. Virol.75(5),2488-2492(2001)
