AA147
Cat. No.：YN480803
CAS No. ：393121-74-9
规格
价格(RMB)
库存
| 产品名称: | AA147 |
| CAS No.: | 393121-74-9 |
| Chemical Name: | N-(2-hydroxy-5-methylphenyl)-benzenepropanamide |
| Synonyms: | ATF6-activator-147 |
| 分子量: | 255.31 |
| 分子式: | C₁₆H₁₇NO₂ |
| SMILES: | O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AA147 是一种小分子内质网 (ER) 蛋白稳态调节剂，选择性激活未折叠蛋白反应 (UPR) 的ATF6臂，详细信息请参考专利文献 WO2017117430A1 中的化合物 147*。 |
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Rosarda, J.D., Baron, K.R., Nutsch, K., et al.Metabolically activated proteostasis regulators protect against glutamate toxicity by activating NRF2ACS Chem. Biol.16(12),2852-2863(2021)
Blackwood, E.A., Azizi, K., Thuerauf, D.J., et al.Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasisNat. Commun.10(1),187(2019)
Almasy, K.M., Davies, J.P., Lisy, S.M., et al.Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infectionsProc. Natl. Acad. Sci. USA118(3),e2012209118(2021)
