K-7174 dihydrochloride
Cat. No.：YN480891
CAS No. ：191089-60-8
规格
价格(RMB)
库存
| 产品名称: | K-7174 dihydrochloride |
| CAS No.: | 191089-60-8 |
| Chemical Name: | hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-1H-1,4-diazepine, dihydrochloride |
| Synonyms: | |
| 分子量: | 641.67 |
| 分子式: | C₃₃H₅₀Cl₂N₂O₆ |
| SMILES: | COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | K-7174二盐酸盐是细胞粘附抑制剂，能抑制VCAM-1的表达量。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kikuchi, J., Shibayama, N., Yamada, S., et al.Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome bindingPLoS One8(4),e60649(2013)
Umetani, M., Nakao, H., Doi, T., et al.A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATABiochem. Biophys. Res. Commun.272(2),370-374(2000)
Kikuchi, J., Yamada, S., Koyama, D., et al.The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylasesJ. Biol. Chem.288(35),25593-25602(2013)
Imagawa, S., Nakano, Y., Obara, N., et al.A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1β, TNF-α, or L-NMMAFASEB J.17(12),1742-1744(2003)
