Genz-123346 free base
Cat. No.：YN480892
CAS No. ：491833-30-8
规格
价格(RMB)
库存
| 产品名称: | Genz-123346 free base |
| CAS No.: | 491833-30-8 |
| Chemical Name: | N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide |
| Synonyms: | Genz-?123346;Genz-123346;N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)nonanamide;Genz-123346 (free base);N-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide; |
| 分子量: | 418.57 |
| 分子式: | C₂₄H₃₈N₂O₄ |
| SMILES: | CCCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Genz-123346是阻断神经酰胺向GL1转化的GL1合酶的抑制剂；抑制GM1IC50值为14 nM。 |
| IC50和靶点: | |
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Zhao, H., Przybylska, M., Wu, I.-H., et al.Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetesDiabetes56(5),1210-1218(2007)
Zhao, H., Przybylska, M., Wu, I.-H., et al.Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese miceHepatology50(1),85-93(2009)
