QS11
Cat. No.：YN480899
CAS No. ：944328-88-5
规格
价格(RMB)
库存
| 产品名称: | QS11 |
| CAS No.: | 944328-88-5 |
| Chemical Name: | βS-[[9-([1,1'-biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]-benzenepropanol |
| Synonyms: | QS 11 |
| 分子量: | 567.68 |
| 分子式: | C₃₆H₃₃N₅O₂ |
| SMILES: | OC[C@H](CC1=CC=CC=C1)NC2=C3C(N(CC4=CC=C(C5=CC=CC=C5)C=C4)C=N3)=NC(OC6=CC=C(CCC7)C7=C6)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | QS11 是一种ARFGAP1抑制剂，其EC50为 1.5 µM。QS11 通过影响蛋白质运输来增强 Wnt/β-catenin 信号。QS11 能抑制 ARFGAP 过表达的乳腺癌细胞迁移。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhang, Q., Major, M.B., Takanashi, S., et al.Small-molecule synergist of the Wnt/β-catenin signaling pathwayProc. Natl. Acad. Sci. USA104(18),7444-7448(2007)
Singh, M.K., Gao, H., Sun, W., et al.Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonistBioorg. Med. Chem. Lett.25(21),4838-4842(2015)
