Desbutyl Lumefantrine
Cat. No.：YN480906
CAS No. ：355841-11-1
规格
价格(RMB)
库存
| 产品名称: | Desbutyl Lumefantrine |
| CAS No.: | 355841-11-1 |
| Chemical Name: | (9Z)-α-[(butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol |
| Synonyms: | Desbutyl-benflumetol |
| 分子量: | 472.83 |
| 分子式: | C₂₆H₂₄Cl₃NO |
| SMILES: | OC(CNCCCC)C1=CC(Cl)=CC(/C2=C\C3=CC=C(Cl)C=C3)=C1C4=C2C=C(Cl)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desbutyl Lumefantrine 是lumefantrine 的一个代谢物，具有抗疟疾活性。 |
| IC50和靶点: | |
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Wong, R.P.M., Salman, S., Ilett, K.F., et al.Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcomeAntimicrob. Agents Chemother.55(3),1194-1198(2011)
Traebert, M., Dumotier, B., Meister, L., et al.Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cellsEur. J. Pharmacol.484(1),41-48(2004)
Abdullahi, S.T., Soyinka, J.O., Olagunju, A., et al.CYP2B6*6 genotype specific differences in artemether-lumefantrine disposition in healthy volunteersJ. Clin. Pharmacol.60(3),351-360(2020)
