KN-92 hydrochloride
Cat. No.：YN481435
CAS No. ：1431698-47-3
规格
价格(RMB)
库存
| 产品名称: | KN-92 hydrochloride |
| CAS No.: | 1431698-47-3 |
| Chemical Name: | 2-[N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, monohydrochloride |
| Synonyms: | Kn-92 (hydrochloride);KN-92 hydrochloride;KN 92 hydrochloride;N-[2-({[3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzene-1-sulfonamide hydrochloride;KN 92;BCP10626;BC600750 |
| 分子量: | 493.45 |
| 分子式: | C₂₄H₂₆Cl₂N₂O₃S |
| SMILES: | O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KN-92 hydrochloride 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 hydrochloride 可作为对照化合物用于阐明 KN-93 的拮抗活性。KN-93 可渗透细胞，可逆和竞争性的 CaMKII 抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sumi, M., Kiuchi, K., Ishikawa, T., et al.The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cellsBiophys. Res. Commun.181(3),968-975(1991)
Tombes, R.M., Grant, S., Westin, E.H., et al.G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase)Cell Growth Differ.6(9),1063-1070(1995)
