3PO
Cat. No.：YN481687
CAS No. ：18550-98-6
规格
价格(RMB)
库存
| 产品名称: | 3PO |
| CAS No.: | 18550-98-6 |
| Chemical Name: | 3-(3-pyridinyl)-1-(4-pyridinyl)-2E-propen-1-one |
| Synonyms: | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
| 分子量: | 210.23 |
| 分子式: | C₁₃H₁₀N₂O |
| SMILES: | O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3PO是一种新型小分子PFKFB3同工酶的抑制剂, 显着衰减几个人恶性造血细胞和腺癌细胞系的增殖 (IC50为1.4-24 μM) 。 |
| IC50和靶点: | |
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Clem, B., Telang, S., Clem, A., et al.Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growthMol. Cancer Ther.7(1),110-120(2008)
Clem, B.F., O'Neal, J., Tapolsky, G., et al.Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancerMol. Cancer Ther.12(8),1461-1470(2013)
Schoors, S., De Bock, K., Cantelmo, A.R., et al.Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesisCell Metab.19(1),37-48(2014)
