Glimepiride
Cat. No.：YN481776
CAS No. ：93479-97-1
规格
价格(RMB)
库存
| 产品名称: | Glimepiride |
| CAS No.: | 93479-97-1 |
| Chemical Name: | 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide |
| Synonyms: | 格列美脲; Glimperide; HOE-490 |
| 分子量: | 490.62 |
| 分子式: | C₂₄H₃₄N₄O₅S |
| SMILES: | O=C(N1C(C(CC)=C(C)C1)=O)NCCC2=CC=C(S(=O)(NC(N[C@H]3CC[C@H](C)CC3)=O)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glimepiride (Glimperide) 是中长效的磺酰脲类抗糖尿病化合物，ED50为 182 μg/k。 |
| IC50和靶点: | |
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Song, D.K., and Ashcroft, F.M.Glimepiride block of cloned β-cell, cardiac and smooth muscle KATP channelsBr. J. Pharmacol.133(1),193-199(2001)
Hribal, M.L., D'Alfonso, R., Giovannone, B., et al.The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoformsMol. Pharmacol.59(2),322-330(2001)
Müller, G., Satoh, Y., and Geisen, K.Extrapancreatic effects of sulfonylureas - a comparison between glimepiride and conventional sulfonylureasDiabetes Res. Clin. Pract.28(Suppl 1),S115-S137(1995)
