Tafluprost
Cat. No.：YN481838
CAS No. ：209860-87-7
规格
价格(RMB)
库存
| 产品名称: | Tafluprost |
| CAS No.: | 209860-87-7 |
| Chemical Name: | 15,15-difluoro-9α,11α-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester |
| Synonyms: | 他氟前列素; AFP-168; MK2452 |
| 分子量: | 452.53 |
| 分子式: | C₂₅H₃₄F₂O₅ |
| SMILES: | O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/C(F)(F)COC2=CC=CC=C2)[C@H](O)C[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tafluprost(AFP-168)是抗青光眼前列腺素（PG）类似物。 |
| IC50和靶点: | |
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Woodward, D.F., Krauss, A.H., Chen, J., et al.The pharmacology of bimatoprost (Lumigan™)Surv. Ophthalmol.45(Suppl. 4),S337-S345(2001)
Abramovitz, M., Adam, M., Boie, Y., et al.The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogsBiochim. Biophys. Acta1483(2),285-293(2000)
Sorbera, L.A., and Castañer, J.TravoprostDrugs Future25(1),41-45(2000)
Maxey, K.M., Johnson, J., and LaBrecque, J.The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonistSurv. Ophthalmol.47(Suppl. 1),S34-S40(2002)
Resul, B., Stjernschantz, J., No, K., et al.Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agentsJ. Med. Chem.36(2),243-248(1993)
Nakajima, T., Matsugi, T., Goto, W., et al.New fluoroprostaglandin F2α derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agentsBiol. Pharm. Bull.26(12),1691-1695(2003)
