FRAX597

Cat. No.：1286739-19-2

CAS No. ：1286739-19-2

产品名称:	FRAX597
CAS No.:	1286739-19-2
Chemical Name:
Synonyms:	FRAX597;6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one;6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one,hydrochloride;
分子量:	558.10
分子式:	C₂₉H₂₈ClN₇OS
SMILES:	O=C1C(C2=CC=C(C3=CN=CS3)C=C2Cl)=CC4=CN=C(NC5=CC=C(N6CCN(C)CC6)C=C5)N=C4N1CC
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Licciulli, S., Maksimoska, J., Zhou, C., et al.FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated SchwannomasJ. Biol. Chem.288(40),29105-29114(2013)', 'Yeo, D., He, H., Patel, O., et al.FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabineBMC Cancer16,24(2016)', 'Prudnikova, T.Y., Villmar-Cruz, O., Rawat, S.J., et al.Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cellsOncogene35(17),2178-2185(2016)', 'Yeo, D., Phillips, P., Baldwin, G.S., et al.Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancerInt. J. Cancer140(9),2101-2111(2017)

摩尔浓度计算器方程 :

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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