Wortmannin
Cat. No.：YN420032
CAS No. ：19545-26-7
规格
价格(RMB)
库存
| 产品名称: | Wortmannin |
| CAS No.: | 19545-26-7 |
| Chemical Name: | 11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione |
| Synonyms: | 渥曼青霉素; SL-2052; KY-12420 |
| 分子量: | 428.43 |
| 分子式: | C₂₃H₂₄O₈ |
| SMILES: | O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C5=C1OC=C5C(O[C@@H]4COC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Wortmannin (SL-2052) 是一种有效的，不可逆的，选择性PI3K抑制剂，IC50值为 3 nM。Wortmannin (SL-2052) 阻断自噬 (autophagy) 形成，并有效抑制Polo-like kinase 1 (PlK1)和Plk3，IC50值分别为 5.8 和 48 nM。 |
| IC50和靶点: | [{name:"PI3K:3 nM (IC50)"},{name: "DNA-PK:16 nM (IC50)"},{name: "PLK3:48 nM (IC50)"},{name: "ATM:150 nM (IC50)"},{name: "ATR:1.8 μM (IC50)"},{name: "MLCK:200 nM (IC50)'}, 'Autophagy'] |
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| Solvent & Solubility: |
Fruman, D.A., Meyers, R.E., and Cantley, L.C.Phosphoinositide kinasesAnnu. Rev. Biochem.67,481-507(2008)
Liu, Y., Shreder, K.R., Gai, W., et al.Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinaseChem. Biol.12,99-107(2005)
Liu, Y., Jiang, N., Wu, J., et al.Polo-like kinases inhibited by wortmannin. Labeling site and downstream effectsJ. Biol. Chem.282(4),2505-2511(2007)
