CH5132799
Cat. No.：YN420216
CAS No. ：1007207-67-1
规格
价格(RMB)
库存
| 产品名称: | CH5132799 |
| CAS No.: | 1007207-67-1 |
| Chemical Name: | 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-pyrimidinamine |
| Synonyms: | CH 5132799; CH-5132799 |
| 分子量: | 377.42 |
| 分子式: | C₁₅H₁₉N₇O₃S |
| SMILES: | NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CH5132799 是一种选择性的 I 类PI3K抑制剂。抑制 PI3Kα,IC50为 14 nM。 |
| IC50和靶点: | [{name:"PI3Kα:14 nM (IC50)"},{name: "PI3Kα-H1047R:5.6 nM (IC50)"},{name: "PI3Kα-E545K:6.7 nM (IC50)"},{name: "PI3Kα-E542K:6.7 nM (IC50)"},{name: "PI3Kγ:36 nM (IC50)"},{name: "PI3Kβ:120 nM (IC50)"},{name: "PI3Kδ:500 nM (IC50)"},{name: "PI3KC2β:5.3 μM (IC50)"},{name: "mTOR:1.6 μM (IC50)"}] |
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| Solvent & Solubility: |
Ohwada, J., Ebiike, H., Kawada, H., et al.Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799Bioorg. Med. Chem. Lett.21(6),1767-1772(2011)
