Leniolisib
Cat. No.：YN420252
CAS No. ：1354690-24-6
规格
价格(RMB)
库存
| 产品名称: | Leniolisib |
| CAS No.: | 1354690-24-6 |
| Chemical Name: | 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-1-propanone |
| Synonyms: | CDZ173 |
| 分子量: | 450.46 |
| 分子式: | C₂₁H₂₅F₃N₆O₂ |
| SMILES: | CCC(N1C[C@@H](NC2=C(CN(C3=CC(C(F)(F)F)=C(OC)N=C3)CC4)C4=NC=N2)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leniolisib (CDZ173)是高效，选择性的PI3Kδ抑制剂。Leniolisib 有潜力用于免疫缺陷类疾病的研究。 |
| IC50和靶点: | [{name:"PI3Kδ:11 nM (IC50)"},{name: "PI3Kα:280 nM (IC50)"},{name: "PI3Kβ:480 nM (IC50)"},{name: "PI3Kγ:2.57 μM (IC50)"},{name: "DNA-PK:880 nM (IC50)"}] |
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| Solvent & Solubility: |
Hoegenauer, K., Soldermann, N., Zécri, F., et al.Discovery of CDZ173 (leniolisib), representing a structurally novel class of PI3K delta-selective inhibitorsACS Med. Chem. Lett.8(9),975-980(2017)
