Rigosertib
Cat. No.：YN420106
CAS No. ：592542-59-1
规格
价格(RMB)
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| 产品名称: | Rigosertib |
| CAS No.: | 592542-59-1 |
| Chemical Name: | [2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetic acid |
| Synonyms: | ON-01910 |
| 分子量: | 451.49 |
| 分子式: | C₂₁H₂₅NO₈S |
| SMILES: | COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制PI3K/Akt途径诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。Rigosertib 是一种选择性的非 ATP 竞争性PLK1抑制剂，IC50值为 9 nM。 |
| IC50和靶点: | [{name:"PLK1:9 nM (IC50)"},{name: "PLK2:260 nM (IC50)"},{name: "PDGFR:18 nM (IC50)"},{name: "Src:155 nM (IC50)"},{name: "BCR-ABL:32 nM (IC50)"},{name: "Cdk1:260 nM (IC50)"},{name: "Flt1:42 nM (IC50)"},{name: "Fyn:182 nM (IC50)"}] |
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| Solvent & Solubility: |
Jost, M. et al.: Mol. Cell., 68, 210 (2018)
