AZD8186
Cat. No.：YN420120
CAS No. ：1627494-13-6
规格
价格(RMB)
库存
| 产品名称: | AZD8186 |
| CAS No.: | 1627494-13-6 |
| Chemical Name: | 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide |
| Synonyms: | AZD-8186;AZD8186;AIQ4OWD0RA;AZD 8186;(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide;4H-1-Benzopyran-6-carboxamide, 8-((1R)-1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-;8-[( |
| 分子量: | 457.47 |
| 分子式: | C₂₄H₂₅F₂N₃O₄ |
| SMILES: | O=C(C1=CC([C@H](NC2=CC(F)=CC(F)=C2)C)=C3C(C(C=C(N4CCOCC4)O3)=O)=C1)N(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD8186 是一种PI3K抑制剂，抑制 PI3Kβ (IC5050=4 nM)，PI3Kδ (IC5050=12 nM)，PI3Kα (IC50=35 nM) 和 PI3Kγ (IC50=675 nM)。 |
| IC50和靶点: | [{name:"PI3Kβ:4 nM (IC50)"},{name: "PI3Kδ:12 nM (IC50)"},{name: "PI3Kα:35 nM (IC50)"},{name: "PI3Kγ:675 nM (IC50)"}] |
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Barlaam, B., Cosulich, S., Degorce, S., et al.Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancersJ. Med. Chem.58(2),943-962(2015)
Hancox, U., Cosulich, S., Hanson, L., et al.Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxelMol. Cancer Ther.14(1),48-58(2015)
