Acalisib
Cat. No.：YN420135
CAS No. ：870281-34-8
规格
价格(RMB)
库存
| 产品名称: | Acalisib |
| CAS No.: | 870281-34-8 |
| Chemical Name: | 6-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone |
| Synonyms: | GS-9820; CAL-120 |
| 分子量: | 401.40 |
| 分子式: | C₂₁H₁₆FN₇O |
| SMILES: | O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C=C(F)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acalisib 是一种有效的选择性PI3Kδ抑制剂，IC50为 12.7 nM。 |
| IC50和靶点: | [{name:"p110α:5441 nM (IC50)"},{name: "p110β:3377 nM (IC50)"},{name: "p110δ:12.7 nM (IC50)"},{name: "p110γ:1389 nM (IC50)"},{name: "hVps34:12682 nM (IC50)"},{name: "DNA-PK:18749 nM (IC50)"}] |
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| Solvent & Solubility: |
Shugg, R.P., Thomson, A., Tanabe, N., et al.Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: Actions on cytoskeletal organization, survival, and resorptionJ. Biol. Chem.288(49),35346-35357(2013)
Sanchez, E., Li, M., Wang, C., et al.Phosphoinositide 3'-knase (PI3K) delta inhibitor, GS-9820, enhances anti-tumor efficacy when combined with conventional chemotherapeutic agents in primary samples and human tumor xenograft model of multiple myelomaBlood120(21),4017(2012)
