AZD-8835
Cat. No.：YN420141
CAS No. ：1620576-64-8
规格
价格(RMB)
库存
| 产品名称: | AZD-8835 |
| CAS No.: | 1620576-64-8 |
| Chemical Name: | 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-1-propanone |
| Synonyms: | AZD8835 |
| 分子量: | 469.54 |
| 分子式: | C₂₂H₃₁N₉O₃ |
| SMILES: | O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD8835 是一种有效的选择性PI3Kα和PI3Kδ 抑制剂，IC50分别为 6.2 和 5.7 nM。 |
| IC50和靶点: | [{name:"PI3Kδ:5.7 nM (IC50)"},{name: "PI3Kα:6.2 nM (IC50)"},{name: "PI3Kα-H1047R:5.8 nM (IC50)"},{name: "PI3Kα-E545K:6 nM (IC50)"},{name: "PI3Kγ:90 nM (IC50)"},{name: "PI3Kβ:431 nM (IC50)"}] |
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| Solvent & Solubility: |
Barlaam, B., Cosulich, S., Delouvrié, B., et al.Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancersBioorg. Med. Chem. Lett.25(22),5155-5162(2015)
Carnevalli, L.S., Sinclair, C., Taylor, M.A., et al.PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activityJ. Immunother. Cancer6(1),158(2018)
