AMG319
Cat. No.：YN420144
CAS No. ：1608125-21-8
规格
价格(RMB)
库存
| 产品名称: | AMG319 |
| CAS No.: | 1608125-21-8 |
| Chemical Name: | 7-fluoro-αS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine |
| Synonyms: | AMG319;AMG-319 |
| 分子量: | 385.40 |
| 分子式: | C₂₁H₁₆FN₇ |
| SMILES: | C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG319 是一种有效的选择性PI3Kδ抑制剂，IC50为 18 nM。 |
| IC50和靶点: | [{name:"PI3Kδ:18 nM (IC50)"},{name: "PI3Kγ:850 nM (IC50)"},{name: "PI3Kβ:2.7 μM (IC50)"},{name: "PI3Kα:33 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cushing, T.D., Hao, X., Shin, Y., et al.Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune diseaseJ. Med. Chem.58(1),480-511(2015)
