PF-4989216
Cat. No.：YN420187
CAS No. ：1276553-09-3
规格
价格(RMB)
库存
| 产品名称: | PF-4989216 |
| CAS No.: | 1276553-09-3 |
| Chemical Name: | 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile |
| Synonyms: | PF 4989216 |
| 分子量: | 380.40 |
| 分子式: | C₁₈H₁₃FN₆OS |
| SMILES: | N#CC1=C(N2CCOCC2)SC(C3=NC=NN3)=C1C4=CC=C(C#N)C=C4F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-4989216 是一种有效的选择性PI3Kα抑制剂，Ki为 0.6 nM。 |
| IC50和靶点: | [{name:"PI3Kα:0.6 nM (Ki)"},{name: "mTOR:1440 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Walls, M., Baxi, S.M., Mehta, P.P., et al.Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216Clin. Cancer Res.20(3),631-643(2014)
