kb NB 142-70
Cat. No.：YN270310
CAS No. ：1233533-04-4
| 产品名称: | kb NB 142-70 |
| CAS No.: | 1233533-04-4 |
| Chemical Name: | 3,4-dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one |
| Synonyms: | kb-NB142-70;3,4-Dihydro-9-hydroxy-[1]benzothieno-[2,3-f]-1,4-thiazepin-5(2H)-one;3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;kb NB 142-70;AG-L-65866;CHEBI:1169969;CHEMBL1672571;CS-1091;CTK8G0429;QCR-15;SureCN9920595;9-hydroxy-3,4-d |
| 分子量: | 251.32 |
| 分子式: | C₁₁H₉NO₂S₂ |
| SMILES: | O=C1NCCSC2=C1SC3=CC=C(O)C=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | kb NB 142-70 是一种有效的PKD抑制剂，对 PKD1，PKD2 和 PKD3 的IC50值分别为 28.3 nM，58.7 nM 和 53.2 nM；kb NB 142-70 同时具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PKD1:28.3 nM (IC50)"},{name: "PKD3:53.2 nM (IC50)"},{name: "PKD2:58.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lavalle, C.R., Bravo-Altamirano, K., Gorodhar, K.V., et al.Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motilityBMC Chem Biol.10(5),(2010)
Young, S.H., Rozengurt, N., Sinnett-Smith, J., et al.Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cellsAm. J. Physiol. Gastrointest. Liver Physiol.303(3),G356-366(2012)
