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DG172 dihydrochloride

Cat. No.：1361504-77-9

  • CAS No. ：1361504-77-9

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    • 产品名称: DG172 dihydrochloride
      CAS No.: 1361504-77-9
      Chemical Name:
      Synonyms:DG172 (dihydrochloride),DG-172 dihydrochloride
      分子量:455.22
      分子式:C₂₀H₂₂BrCl₂N₃
      SMILES:BrC(C=CC=C1)=C1/C(C#N)=C/C(C=C2)=CC=C2N3CCN(C)CC3.[H]Cl.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Lieber, S., Scheer, F., Meissner, W., et al.(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic propertiesJ. Med. Chem.55(6),2858-2868(2012)', 'Lieber, S., Scheer, F., Finkernagel, F., et al.The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiationMol. Pharmacol.87(2),162-173(2015)', 'Adhikary, T., Brandt, D.T., Kaddatz, K., et al.Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasionOncogene32(44),5241-5252(2013)
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