BB-Cl-Amidine
Cat. No.：YN310109
| 产品名称: | BB-Cl-Amidine |
| CAS No.: | 1802637-39-3 |
| Chemical Name: | N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide |
| Synonyms: | |
| 分子量: | 459.97 |
| 分子式: | C₂₆H₂₆ClN₅O |
| SMILES: | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=CC=CC=C4N3)CCCNC(CCl)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BB-Cl-Amidine 是肽基精氨酸脱胺酶(PAD)的抑制剂。 |
| IC50和靶点: | |
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Knight, J.S., Subramanian, V., O'Dell, A.A., et al.Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr miceAnn. Rheum. Dis.74(12),2199-2206(2015)
Luo, Y., Arita, K., Bhatia, M., et al.Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterizationBiochemistry45(39),11727-11736(2006)
Muth, A., Subramanian, V., Beaumont, E., et al.Development of a selective inhibitor of protein arginine deiminase 2.J. Med. Chem.60(7),3198-3211(2017)
