RI-1
Cat. No.：YN290343
CAS No. ：415713-60-9
| 产品名称: | RI-1 |
| CAS No.: | 415713-60-9 |
| Chemical Name: | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione |
| Synonyms: | RAD51 inhibitor 1 |
| 分子量: | 361.61 |
| 分子式: | C₁₄H₁₁Cl₃N₂O₃ |
| SMILES: | O=C(C(N1CCOCC1)=C2Cl)N(C3=CC=C(Cl)C(Cl)=C3)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RI-1 是一种选择性RAD51的抑制剂，IC50值为 5-30 μM。RI-1 在半胱氨酸 319 处与 RAD51 蛋白表面共价结合。RI-1 通过直接结合到 RAD51 细丝中蛋白质亚基之间的界面的蛋白质表面来灭活 RAD51。RI-1 可以破坏人类细胞中的同源重组。 |
| IC50和靶点: | |
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Budke, B., Logan, H.L., Kalin, J.H., et al.RI-1: A chemical inhibitor of RAD51 that disrupts homologous recombination in human cellsNucleic Acids Res.40(15),7347-7357(2012)
Budke, B., Kalin, J.H., Pawlowski, M., et al.An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivityJ. Med. Chem.56(1),254-263(2013)
