BI-882370
Cat. No.：YN350054
CAS No. ：1392429-79-6
| 产品名称: | BI-882370 |
| CAS No.: | 1392429-79-6 |
| Chemical Name: | N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Synonyms: | BI882370,BI-882370 |
| 分子量: | 569.67 |
| 分子式: | C₂₈H₃₃F₂N₇O₂S |
| SMILES: | CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BI-882370 是一种高效选择性的RAF激酶抑制剂，其结合位于 BRAF 激酶的 DFG-out 无活性构象处 (ATP 结合位点)。 BI-882370 抑制 BRAFV600E-mutant, WT BRAF 和 CRAF 激酶的IC50值分别为 0.4，0.8 和 0.6 nM。BI-882370 也可以抑制 SRC 家族激酶。 |
| IC50和靶点: | [{name:"Braf:0.6 nM (IC50)"},{name: "c-Raf:0.8 nM (IC50)"},{name: "BRafV600E:0.4 nM (IC50)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Waizenegger, I.C., Baum, A., Steurer, S., et al.A novel RAF kinase inhibitor with DFG-out-binding mode: High efficacy in BRAF-mutant tumor xenograft models in the absence of normal tissue hyperproliferationMol. Cancer. Ther.15(3),354-365(2016)
