GDC-0879
Cat. No.：YN350212
CAS No. ：905281-76-7
| 产品名称: | GDC-0879 |
| CAS No.: | 905281-76-7 |
| Chemical Name: | 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one, oxime |
| Synonyms: | AR-00341677 |
| 分子量: | 334.37 |
| 分子式: | C₁₉H₁₈N₄O₂ |
| SMILES: | O/N=C1C(C=CC(C2=CN(CCO)N=C2C3=CC=NC=C3)=C4)=C4CC/1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GDC-0879 是一种有效的选择性B-Raf抑制剂，IC50为 0.13 nM。 |
| IC50和靶点: | [{name:"B-Raf:0.13 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wong, H., Belvin, M., Herter, S., et al.Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: Understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacyJ. Pharmacol. Exp. Ther.329(1),360-367(2009)
