TAK-632
Cat. No.：YN350168
CAS No. ：1228591-30-7
| 产品名称: | TAK-632 |
| CAS No.: | 1228591-30-7 |
| Chemical Name: | N-[5-[[7-cyano-2-[(cyclopropylcarbonyl)amino]-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoromethyl)-benzeneacetamide |
| Synonyms: | TAK 632; TAK632 |
| 分子量: | 554.52 |
| 分子式: | C₂₇H₁₈F₄N₄O₃S |
| SMILES: | O=C(NC1=CC(OC2=CC=C3N=C(NC(C4CC4)=O)SC3=C2C#N)=CC=C1F)CC5=CC=CC(C(F)(F)F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAK-632 是一种有效的pan-RAF抑制剂，作用于CRAF，BRAFV600E和BRAFWT，IC50分别为 1.4，2.4 和 8.3 nM。 |
| IC50和靶点: | [{name:"c-Raf:1.4 nM (IC50)"},{name: "Braf:8.3 nM (IC50)"},{name: "Aurora B:66 nM (IC50)"},{name: "PDGFRβ:120 nM (IC50)"},{name: "PDGFRα:610 nM (IC50)"},{name: "FGFR3:280 nM (IC50)"},{name: "TIE2:740 nM (IC50)"},{name: "IKKβ:3700 nM (IC50)"},{name: "CDK1:790 nM (IC50)"},{name: "CDK2:580 nM (IC50)"},{name: "p38α:600 nM (IC50)"},{name: "GSK3β:500 nM (IC50)"},{name: "MEK1:3700 nM (IC50)"}] |
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Okaniwa, M., Hirose, M., Arita, T., et al.Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: Design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivativesJ. Med. Chem.56(16),6478-6494(2013)
Nakamura, A., Arita, T., Tsuchiya, S., et al.Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanomaCancer Res.73(23),7043-7055(2013)
