AT7867
Cat. No.：YN350101
CAS No. ：857531-00-1
规格
价格(RMB)
库存
| 产品名称: | AT7867 |
| CAS No.: | 857531-00-1 |
| Chemical Name: | 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-piperidine |
| Synonyms: | AT-7867;AT 7867 |
| 分子量: | 337.85 |
| 分子式: | C₂₀H₂₀ClN₃ |
| SMILES: | ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT7867 是一种 ATP 竞争性的Akt1/Akt2/Akt3和p70S6K/PKA抑制剂，IC50分别为 32 nM/17 nM/47 nM 和 85 nM/20 nM。 |
| IC50和靶点: | [{name:"Akt2:17 nM (IC50)"},{name: "p70S6K:85 nM (IC50)"},{name: "Akt1:32 nM (IC50)"},{name: "Akt3:47 nM (IC50)"},{name: "PKA:20 nM (IC50)"}] |
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| Solvent & Solubility: |
Grimshaw, K.M., Hunter, L.-J.K., Yap, T.A., et al.AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growthMol. Cancer Ther.9(5),1100-1110(2010)
