LJI308
Cat. No.：YN350203
CAS No. ：1627709-94-7
| 产品名称: | LJI308 |
| CAS No.: | 1627709-94-7 |
| Chemical Name: | 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-phenol |
| Synonyms: | LJI-308,LJI 308，LJI308 |
| 分子量: | 368.38 |
| 分子式: | C₂₁H₁₈F₂N₂O₂ |
| SMILES: | OC1=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LJI308是新型有效的RSK抑制剂, 抑制RSK1, RSK2, 和RSK3 IC50值分别为6 nM, 4 nM, 和13 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Aronchik, I., Appleton, B.A., Basham, S.E., et al.Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancersMol. Cancer Res.12(5),803-812(2014)
Jain, R., Mathur, M., Lan, J., et al.Discovery of potent and selective RSK inhibitors as biological probesJ. Med. Chem.58(17),6766-6783(2015)
